[4P] Neurodevelopmental Disorders

[4P-408] Mice with Scn2a deficiency specifically in striatal medium spiny neurons displayed decreased anxiety and mild impairments of social behavior

〇Toshimitsu Suzuki^1,2, Tetsuya Tatsukawa², Chihiro Hisatsune^3,4, Katsuhiko Mikoshiba^3,5,6, Kazuhiro Yamakawa^1,2 (1.Dept Neurodevelopmental Disorder Genetics, IBS, Grad Sch Med, Nagoya City Univ, Nagoya, Japan, 2.Lab for Neurogenetics, CBS, RIKEN, Wako, Japan, 3.Lab for Developmental Neurobiology, CBS, RIKEN, Wako, Japan, 4.Synaptic Plasticity Project, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan, 5.Shanghai Institute for Advanced Immunochemical Studies, ShanghaiTech University, Shanghai, China, 6.Faculty of Science, Toho University, Funabashi, Japan)

Keywords:SCN2A, Nav1.2, autism spectrum disorder, medium spiny neurons