[4P] Depression and Bipolar Disorders

[4P-439] Down-regulation of a mitochondrial gene in the affected haplotype of bipolar disorder family: Allele-specific expression analysis using iPSC-derived neurons

〇Gakuya Takamatsu^1,2, Kumiko Yanagi⁵, Yoko Nanome⁴, Kae Koganebuchi⁶, Junseok Lee¹, Kanako Toyama¹, Dimitar Dimitrov⁹, Minami Hasegawa⁴, Tomoko Hayakawa¹⁰, Kotarou Hattori^7,8, Hiroshi Kunugi^7,11, Tsuyoshi Kondo², Tomoyuki Takahashi⁹, Hirotaka James Okano⁴, Ryosuke Kimura³, Tadashi Kaname⁵, Masayuki Matsushita¹ (1.Dept of Mol Cell Physiol, Grad Sch Med, Univ of the Ryukyus, Okinawa, Japan, 2.Dept of Neuropsy, Grad Sch Med, Univ of the Ryukyus, Okinawa, Japan, 3.Dept of Hum Biol Anat, Grad Sch Med, Univ of the Ryukyus, Okinawa, Japan, 4.Div of Regen Med, Jikei Univ Sch of Med, Tokyo, Japan, 5.Dept of Gen Med, Natl Ctr for Chd Hlth Dev, Tokyo, Japan, 6.Dept of Biol Sci, Grad Sch of Sci, Univ of Tokyo, Tokyo, Japan, 7.Dept of Ment Dis Res, Natl Inst of Natl Ctr of Neur Psyc, Tokyo, Japan, 8.Med Gen Cent, Natl Ctr of Neur Psyc, Tokyo, Japan, 9.Cel and Mol Syn Func Unit, Okinawa Inst of Sci Tech Grad Univ, Okinawa, Japan, 10.Dept of Phamc, Jichi Med Univ, Tochigi, Japan, 11.Dept of Psych, Teikyo Univ Sch of Med, Tokyo, Japan)

Keywords:Bipolar disorder, patient-derived, iPS cell, mitochondria