[4P] Neural Circuit Manipulation

[4P-475] An engineered channelrhodopsin optimized for axon terminal activation and circuit mapping

〇Shun Hamada¹, Masashi Nagase², Tomohiko Yoshizawa^3,4,6, Akari Hagiwara^1,5, Yoshikazu Isomura^3,4, Ayako M Watabe², Toshihisa Ohtsuka¹ (1.Dep Biochem, Fac Med, Univ of Yamanashi, Yamanashi, Japan, 2.Inst Clin Med and Res, Res Center Med Sci, Jikei Univ Sch of Med, Chiba, Japan, 3.Dep Physiol Cell Biol, Grad Sch Med Dent Sci, Tokyo Med Dent Univ, Tokyo, Japan, 4.Brain Sci Inst, Tamagawa Univ, Tokyo, Japan, 5.Dep Appl Biol Sci, Fac Sci and Tech, Tokyo Univ of Sci, Chiba, Japan, 6.Dep Oral Phys, Div Oral Func Sci, Grad Sch Dent Med, Hokkaido Univ, Hokkaido, Japan)

Keywords:Optogenetics, presynaptic terminal, channelrhodopsin, circuit mapping