○Yuki Uchida¹, Shotaro Kamijo², Yuki Samejima^1,3, Motoyasu Honma¹, Yuri Masaoka¹, Masahiko Izumizaki¹ (1. Department of Physiology, Showa University School of Medicine, Shinagawa, Tokyo, Japan, 2. Division of Physiology, Toxicology and Therapeutics, Department of Pharmacology, Showa University, Shinagawa, Tokyo, Japan, 3. Department of Orthopaedic Surgery, Showa University Fujigaoka Hospital, Yokohama, Japan)