[4S06m] Structural and molecular plasticity linked to chronic pain and its recovery

Support contributed by Tianqiao and Chrissy Chen Institute.

Fri. Aug 4, 2023 9:00 AM - 11:00 AM Room 6 (Shirakashi 1)

Organizer: Makoto Tsuda (Department of Molecular and System Pharmacology, Graduate School of Pharmaceutical Sciences, Kyushu University), Xiaoke Chen (Department of Biology, Stanford University)

A lesion or disease in the somatosensory system might cause chronic pain. Its typical symptoms are increased pain from a stimulus that normally provokes pain (hyperalgesia) or pain due to a stimulus that does not normally painful (allodynia). However, mechanisms underlying such pain sensitization are largely unknown. In this symposium, researchers who have investigated the structural and molecular changes linked to chronic pain and its recovery will show the latest, interesting data from their studies using cutting edge technologies including in vivo brain imaging, circuits mapping, and cell-type/circuits-specific manipulations, and will also discuss the perspectives for the development of new analgesics.

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[4S06m-01] Structural plasticity in neural pathways and peripheral miswiring of sensory end organs in neuropathic pain

○Rohini Diwakar Kuner¹ (1. Institute of Pharmacology, University of Heidelberg)

[4S06m-02] Multiscale analysis of cortical structural plasticity in chronic pain reveals neuronal loss in secondary motor cortex

○Thomas Kuner¹ (1. Heidelberg University)

[4S06m-03] Brain circuits involved in neuropathic pain

○Gerald W Zamponi¹ (1. Dept Clin Neurosci, University of Calgary, Calgary, Canada)

[4S06m-04] Circuitry and Molecular Mechanisms of Descending Pain Facilitation

○xiaoke chen¹, qian wang¹, Greg Nachtrab¹ (1. Department of Biology, Stanford University, USA)

[4S06m-05] Control of neuropathic pain development and recovery by spinal glial cells

○Makoto Tsuda¹ (1. Department of Molecular and System Pharmacology, Graduate School of Pharmaceutical Sciences, Kyushu University)