[1Pm] Neurodevelopmental Disorders

[1Pm-179] Maternal immune activation by excess IL-17a caused offspring abnormalities in social and exploratory behavior, dendritic spine development in the prefrontal cortex, and fetal autonomic nervous system.

○Ken Ishikawa¹, Yuta Momono^2,3, Yuki Murakami⁴, Chihiro Yoshida², Yoshitaka Kimura², Yoshiyuki Kasahara², Masatoshi Saito^2,3 (1. Department of Medical Sciences, School of Medicine, Tohoku University, Miyagi, Japan, 2. Department of Maternal and Fetal Therapeutics, Tohoku University Graduate School of Medicine, Miyagi, Japan, 3. Department of Gynecology and Obstetrics, Tohoku University Graduate School of Medicine, Miyagi, Japan, 4. Department of Hygiene and Public Health, Kansai Medical University, Osaka, Japan)

Keywords:neurodevelopmental disorder, maternal immune activation, interleukin-17a, autonomic nervous system