[1S10a] 加齢と神経変性疾患における神経ホメオスタシス制御の最前線

[1S10a-04] Endothelial TFEB signaling-mediated autophagic disturbance initiates microglial activation and cognitive dysfunction

○Ying-Mei Lu¹, Ya-Ping Lu¹, Xiang Chen², Xiu-Xiu Liu², Yi Shi¹, Zhao-Cong Wei¹, Li-Li Feng², Quan Jiang³, Wei-Feng Ye⁴, Takuya Sasaki⁵, Kohji Fukunaga⁵, Yong Ji², Feng Han² (1. School of Basic Medical Sciences, Nanjing Medical University, Nanjing, China, 2. School of Pharmacy, Nanjing Medical University, Nanjing, China, 3. College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China, 4. Department of Pharmacy, The Children’s Hospital, Zhejiang University School of Medicine, Hangzhou, China, 5. Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, Japan)

キーワード：Cognitive dysfunction, Autophagy, Microglia