[2Pa] Neurotransmitters and Signaling Molecules

[2Pa-012] Phosphoproteomic of the NMDA pathway enables discovery of the CaMKII-RhoGEF-Rho-kinase-SHANK3 cascade as a stimulatory signal for aversive learning

○Yasuhiro Funahashi^1,2, Rijwan Uddin Ahammad^1,2, Xinjian Zhang³, Emran Hossen^1,3, Md. Omar Faruk^1,2, Minhua Wu⁵, Huanhuan Wang^1,2, Xu Li^1,2, Keisuke Kuroda⁴, Daisuke Tsuboi^1,2, Tomoki Nishioka¹, Mutsuki Amano⁴, Kenji Sakimura⁶, Shigeo Uchino⁷, Kiyofumi Yamada⁵, Taku Nagai³, Kozo Kaibuchi1^1,2 (1. Center for Medical Science, Fujita Health University, Aichi, Japan, 2. Division of Cell Biology, International Center for Brain Science (ICBS), Fujita Health University, Aichi, Japan, 3. Division of Behavioral Neuropharmacology, International Center for Brain Science (ICBS), Fujita Health University, Aichi, Japan, 4. Department of Cell Pharmacology, Nagoya University Graduate School of Medicine, Aichi, Japan, 5. Department of Neuropsychopharmacology and Hospital Pharmacy, Nagoya University Graduate School of Medicine, Aichi, Japan, 6. Department of Animal Model Development, Brain Research Institute, Niigata University, Niigata, Japan, 7. Department of Biosciences, School of Science and Engineering, Teikyo University, Tochigi, Japan)

Keywords:Glutamate, Phosphorylation, Learning, Synaptic plasticity