[2Pa] Alzheimer's Disease and Dementia

[2Pa-154] Diabetes mellitus aggravates behavioral deficit via a site-specific phosphorylation of tau protein in Alzheimer’s disease mouse model

○Yuki Ito^1,2, Shuko Takeda^1,2, Tsuneo Nakajima³, Akane Oyama^2,3, Hikari Takeshita³, Kunihiro Miki¹, Yoichi Takami³, Yasushi Takeya^3,4, Munehisa Shimamura⁵, Hiromi Rakugi³, Ryuichi Morishita¹ (1. Department of Clinical Gene Therapy, Graduate School of Medicine, Osaka University, Osaka, Japan, 2. Osaka Psychiatric Research Center, Osaka Psychiatric Medical Center, Osaka, Japan, 3. Department of Geriatric and General Medicine, Graduate School of Medicine, Osaka University, Osaka, Japan, 4. Department of Clinical Nursing, Division of Health Sciences, Graduate School of Medicine, Osaka University, Osaka, Japan, 5. Department of Gene and Stem Cell Regenerative Therapy, Graduate School of Medicine, Osaka University, Osaka, Japan)

Keywords:Alzheimer’s disease, diabetes mellitus, tau, post-translational modification