[2Pm] Sleep and Biological Rhythms

[2Pm-060] Chronic sleep fragmentation induces earlier development of prodromal symptoms and phosphorylated α-synuclein pathology in prodromal Parkinson’s disease model mice

○Masayuki Miyazaki^1,2,3, Hiroko Yagihara¹, Hiromi Fujita⁴, Hodaka Yamakado⁵, Keiji Wada⁴, Eiko N Minakawa¹ (1. Dept Neurophys, Natl Inst Neurosci, NCNP, Tokyo, Japan, 2. Grad Sch Med Dent Sci, Tokyo Med and Dent Univ, Tokyo, Japan, 3. Research Fellow of JSPS, JSPS, Tokyo, Japan, 4. Dept Degen Neurol Dis, Natl Inst Neurosci, Natl Ctr of Neurol and Psychiatr, Tokyo, Japan, 5. Dept Neurol, Grad Sch Med, Kyoto Univ, Kyoto, Japan)

Keywords:Sleep fragmentation, Parkinson's disease, Prodromal phase