[3O08e-2] Molecular, Biochemical and Genetic Techniques

[3O08e-2-01] Förster resonance energy transfer-based kinase mutation phenotyping reveals an aberrant facilitation of Ca²⁺/calmodulin-dependent CaMKIIα activity in de novo mutations related to intellectual disability

○Hajime Fujii¹, Hiroyuki Kidokoro², Yayoi Kondo¹, Masahiro Kawaguchi², Shin-ichiro Horigane^3,4, Jun Natsume ^2,5, Sayaka Takemoto-Kimura^3,4, Haruhiko Bito¹ (1. Dept of Neurochem, Grad Sch Med, Univ of Tokyo, Tokyo, Japan, 2. Dept of Pediatrics, Nagoya Univ Grad Sch of Med, Nagoya, Japan, 3. Dept of Neuroscience I, RIEM, Nagoya Univ, Nagoya, Japan, 4. Molecular/Cellular Neuroscience, Nagoya Univ Grad Sch of Medicine, Nagoya, Japan, 5. Dept of Developmental Disability Medicine, Nagoya Univ Grad Sch of Medicine, Nagoya, Japan)

Keywords:Ca2+ signaling, Fluorescent probe imaging, Intellectual disability, CaMKII