[3Pa] Neurodegenerative Disorders

[3Pa-104] Longitudinal assessment of serum neurofilament light chain levels during disease progression from asymptomatic to symptomatic phase in polyglutamine disease model marmosets

○Terumi Nakatani¹, Akito Kosugi¹, Harutsugu Tatebe², Takahiko Tokuda², Edward J. Wild³, Yasuko Nakamura¹, Satoru Noguchi¹, Masashi Koizumi¹, Akiyo Kawanobe¹, Shioko Kojima¹, Yuko Saito⁴, Naotake Nogami¹, Kensuke Owari¹, Yoshitaka Nagai⁵, Ikuo Tomioka⁶, Eiko N. Minakawa¹, Kazuhiko Seki¹ (1. National Institute of Neuroscience, National Center of Neurology and Psychiatry, 2. Institute for Quantum Medical Science, National Institutes for Quantum Science and Technology, 3. UCL Queen Square Institute of Neurology, UCL, London, UK, 4. Department of Neuropathology, Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology, 5. Faculty of Medicine, Kindai University, 6. Faculty of Agriculture, Shinshu University)

Keywords:neurofilament light chain (NfL), transgenic marmoset , polyglutamine disease, longitudinal study