[3Pa] Neurodegenerative Disorders

[3Pa-174] FUS suppresses RAN translation and neurodegeneration in C9orf72-linked ALS/FTD through modulating the higher-order structures of GGGGCC repeat RNA

○Yuzo Fujino^1,2, Morio Ueyama¹, Daisaku Ozawa¹, Hayato Ito³, Hideki Taguchi³, Toshiki Mizuno², Yoshitaka Nagai^1,4 (1. Department of Neurology, Kindai University Faculty of Medicine, 2. Department of Neurology, Kyoto Prefectural University of Medicine, 3. School of Life Science and Technology, Tokyo Institute of Technology, 4. Life Science Research Institute, Kindai University)

Keywords:repeat-associated non-AUG translation, C9-ALS/FTD, RNA binding protein, Drosophila