[3Pm] Depression and Bipolar Disorders

[3Pm-166] Small molecule-driven NLRP3 inflammasome inhibition to alleviate chronic stress-induced microglial activation by regulating mitophagy

○Naijun Yuan^1,2,3, Wenjun Zhu³, Qingyu Ma³, Jiaxu Chen³ (1. Shenzhen People’s Hospital, 2nd Clinical Medical College, Jinan University, Shen zhen, China, 2. Integrated Chinese and Western Medicine Postdoctoral Research Station, JNU, Guangzhou, China, 3. Guangzhou Key Laboratory of Formula-pattern Research Center, JNU, Guangzhou, China )

Keywords:Chronic stress, Depression, Neuroinflammation, NLRP3 inflammasome