Kiyoshi Egawa¹, YOSHIHIRO HIRATA¹, HIDEAKI SHIRAISHI¹, DAISUKE SATO¹, SHINJI SAITOH², YUKITOSHI TAKAHASHI³, HIRONOBU OKUNO⁴, MITSURU ISHIKAWA⁴, HIDEYUKI OKANO⁴ (1.Department of Pediatrics, Hokkaido University Graduate School of Medicine, Hokkaido, Japan, 2.Department of Neonatology and Pediatrics, Nagoya City University Graduate School of Medical Sciences, Aichi, Japan, 3.Department of Pediatrics, National Epilepsy Center Shizuoka Institute of Epilepsy and Neurological Disorders, Shizuoka, Japan, 4.Department of Physiology, Keio University School of Medicine, Tokyo, Japan)

Ikumi Hori¹, Fuyuki Miya^2,3, YUJI NAKAMURA¹, DAISUKE IEDA¹, YUTAKA NEGISHI¹, AYAKO HATTORI¹, TATSUHIKO TSUNODA^2,3, YONEHIRO KANEMURA^4,5, KENJIRO KOSAKI⁶, SHINJI SAITOH¹ (1.Department of Pediatrics and Neonatology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan, 2.Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan, 3.Center for Integrative Medical Sciences, RIKEN, Yokohama, Japan, 4.Division of Regenerative Medicine, Institute for Clinical Research, Osaka National Hospital, National Hospital Organization, Osaka, Japan)

Yutaka Negishi¹, DAISUKE IEDA¹, YUJI NAKAMURA¹, IKUMI HORI¹, AYAKO HATTORI¹, YASUYUKI NOZAKI², HIROFUMI KOMAKI³, JUN TOHYAMA⁴, KEISUKE NAGASAKI⁵, HIROKO TADA⁶, HISASHI OISHI⁷, SHINJI SAITOH¹ (1.Department of Pediatrics and Neonatology, Nagoya City University Graduate Sc hool of Medical Sciences, Nagoya, Japan, 2.Department of Pediatrics, Jichi Medical University , Tochigi, Japan, 3.Department of Child Neurology , National Center Hospital, National Center of Neurology and Psychiatry (NCNP) , Tokyo , Japan, 4.Department of Child Neurology Nishi-Niigata Chuo National Hospital Niigata, Japan)

Yuri Sakaguchi^1,2, TOSHIKI TAKENOUCHI¹, KENJIRO KOSAKI², TAKAO TAKAHASHI¹ (1.Department of Pediatrics, Keio University School of Medicine, Tokyo, Japan, 2.Center for Medical Genetics, Keio University School of Medicine, Tokyo, Japan)

Tatsuya Kishino (Division of Functional Genomics, Center for Frontier Science, Nagasaki University, Nagasaki, Japan)

Ken Inoue¹, Kenji Kurosawa², Hirotomo Saitsu³, Toshiyuki Yamamoto⁴, Hitoshi Osaka⁵, Jun-ichi Takanashi⁶ (1.Dept. Mental Retardation & Birth Defect Research, National Institute of Neuroscience, NCNP, Tokyo, Japan, 2.Division of Genetics, Kanagawa Children's Medical Center, Yokohama, Japan, 3.Department of Biochemistry, Hamamatsu University School of Medicine, Hamamatsu, Japan, 4.Tokyo Women's Medical University, Tokyo, Japan, 5.Division of Pediatrics, Niigata University Graduate School of Medical and De ntal Sciences, Niigata, Japan, 6.Pediatrics, Yachiyo Medical Center, Tokyo Women's Medical University, Yachiyo, Japan)