ALPS Poster Session 2

[ALPSp2-26] Laser-mediated nanoparticle delivery to achieve cutaneous siRNA targeting for mitigating psoriasiform inflammation

*Jia-You Fang¹, Woan-Ruoh Lee², Chien-Yu Lin¹ (1. Chang Gung University, 2. Taipei Medical University)

Herein, we developed a delivery system for siRNA based on poly(lactic-co-glycolic acid) (PLGA) nanoparticles and combined this system with ablative laser to promote skin permeation. The siRNA absorption enhancement was compared by two laser modalities: fractional CO₂ laser and fully-ablative Er:YAG laser. Topical application of fractional laser-assisted nanoparticle delivery on mice resulted in 56% of IL-6 knockdown.