Session 4

[BISC4-02] In-vivo intelligent fluorescence sectioning using meta-varifocal endo-microscopy

*Min-Xuan Wang^1,2, Yu-Hsin Chia^1,3, Cheng Hung Chu ⁴, Sunil Vyas ¹, Yi-You Huang ^1,3,5, Din Ping Tsai ^6,7,8, Kuang-Yuh Huang², Yuan Luo ^1,4,9 (1. Institute of Medical Device and Imaging, National Taiwan University, 2. Department of Mechanical Engineering, National Taiwan University, 3. Department of Biomedical Engineering, National Taiwan University, 4. YongLin Institute of Health, National Taiwan University, 5. Department of Biomedical Engineering, National Taiwan University Hospital, 6. Department of Electrical Engineering, City University of Hong Kong, 7. Centre for Biosystems, Neuroscience and Nanotechnology, City University of Hong Kong, 8. The State Key Laboratory of Terahertz and Millimeter Waves, City University of Hong Kong, 9. Program for Precision Health and Intelligent Medicine, National Taiwan University)

Endo-microscopy with structured illumination HiLo imaging process can provide sectioning ability. However, moving optical elements in the axial direction for the 3D imaging restricts compact endoscopic system design. In addition, HiLo imaging requires multiple shots, which is time-consuming and make system configuration complicated. Here, we propose an in-vivo intelligent fluorescence sectioning using meta-varifocal endo-microscopy.