Symposium

[S18] Cutting edge of the membrane transport protein research ~from physiology, structure to the drug development~

Thu. Mar 26, 2020 4:15 PM - 6:15 PM [Room V] Annex Hall 1 (1F)

Organizers: Kazuhiro Abe (Grad Sch Pham Sci, CeSPI, Nagoya Univ), Tappei Takada (Dept Pharm, Univ Tokyo Hosp)

Asymmetric distribution of materials across the biological membrane is no doubt important basis of the living system, which is generated/maintained by membrane transport proteins including channels, transporters and pumps. Given the asymmetry is required not only for the homeostasis of individual cells but also for the characteristics of the respective tissues, disorder in function/regulation of these membrane transport proteins is closely related to various diseases. It is therefore not surprising that membrane transport proteins are recognized as important drug targets.
In this symposium, researchers working on the membrane transport proteins employing biochemical, structural, physiological, chemical biological approach will present their latest results to answer essential questions regarding their molecular mechanisms and physiological relevance. We would also like to discuss the logistics how these outputs from the basic science can be applied for the actual drug development.

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4:15 PM - 4:35 PM

[S18-1] Crystal structures of the gastric proton pump - molecular basis for the binding of acid suppressants, H+-extrusion and K+-counter-transport

○Kazuhiro Abe^1,2 (1. CeSPI, Nagoya Univ, 2. Grad Sch Pharm Sci, Nagoya Univ)

4:35 PM - 4:59 PM

[S18-2] Novel mechanisms in pathophysiology of sodium-dependent P-type ATPase

Takuto Fujii¹, Takahiro Shimizu¹, ○Hideki Sakai¹ (1. Fac Pharm Sci, Univ Toyama)

4:59 PM - 5:23 PM

[S18-3] Function and structure of heterodimeric amino acid transporters: toward the understanding of their physiological properties and pharmaceutical relevance

○Pattama Wiriyasermkul¹, Shushi Nagamori¹ (1. Dept Collab Res Bio-Mol Dyn, Nara Med Univ)

5:23 PM - 5:47 PM

[S18-4] Biochemical and mutational analysis of Plasmodium falciparum chloroquine resistance transporter (PfCRT)

○Hiroshi Omote¹, Narinobu Juge², Tomomi Kinoshita¹, Haruka Iwai¹, Tomoya Fukui¹, Sawako Moriyama¹, Takaaki Miyaji², Yoshinori Moriyama¹ (1. Okayama Univ, Grad Sch Med Dent Pharm Sci, 2. Okayama Univ, Advanced Sci Res Center)

5:47 PM - 6:11 PM

[S18-5] CFTR protein quality control mechanism and its application to CF drug discovery

○Tsukasa Okiyoneda¹ (1. Dept BioMed Chem, Kwansei Gakuin Univ)

6:11 PM - 6:15 PM

[S18-Closing] Closing remarks

Tappei Takada¹ (1. Dept Pharm, Univ Tokyo Hosp)

Session information