[S09] How was the original drug discovery research born? --2020 Breakthrough Award of the Division of Medicinal Chemistry, PSJ and 2019 Award for Excellent General Presentation in the Medicinal Chemistry Symposium--

Sat. Mar 27, 2021 1:15 PM - 3:15 PM [Room I] Oral Presentation I (Online)

Organizer: Habashita Hiromu (Ono Pharmaceutical Co., Ltd.), Otaka Akira (Faculty of Pharm. Sci., Tokushima Univ.), Aoki Kazumasa (Daiichi Sankyo Co., Ltd.)

Division of Medicinal Chemistry at The Pharmaceutical Society of Japan commends research results, including innovative content that contributes to the development of drug discovery, as Breakthrough Award of the Division of Medicinal Chemistry, PSJ. Specifically, the awards are given to original research on drugs or bioactive compounds that have a novel chemical structure as pharmaceuticals, and original research that contributes to drug discovery with new technologies and methods. In addition, from the general oral presentations and poster presentations at the Medical Chemistry Symposium, several research results including remarkable contents that contribute to the progress and future development of drug discovery are commended as Award for Excellent General Presentation in the Medicinal Chemistry Symposium. At this symposium, the award ceremony and award lecture of the 2020 Breakthrough Award of the Division of Medicinal Chemistry, PSJ, and the award lecture of the 2019 Award for Excellent General Presentation in the Medicinal Chemistry Symposium will be given. We hope that through the active sharing of knowledge and experience of these excellent research results, new ideas that will lead to the identification of breakthrough new drugs will be born.

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オーガナイザー挨拶：巾下広（小野薬品工業） (1:15 PM - 1:20 PM)

1:20 PM - 1:40 PM

[S09-1] Design, construction, and screening of a one-bead-one-compound library for discovery of potent analogues of antibiotic lysocin E

○Kotaro Tokumoto¹, Takuya Kaji¹, Hiroaki Itoh¹, Masayuki Inoue¹ (1. Grad. Sch. Pharm. Sci., The Univ. of Tokyo)

1:40 PM - 2:00 PM

[S09-2] Discovery of TAS-116 as a novel orally available HSP90 inhibitor

○Takao Uno¹, Yuichi Kawai¹, Satoshi Yamashita¹, Hiromi Oshiumi¹, Chihoko Yoshimura¹, Takashi Mizutani¹, Tatsuya Suzuki¹, Khoon Tee Chong¹, Kazuhiko Shigeno¹, Mitsuru Ohkubo¹, Yasuo Kodama¹, Hiromi Muraoka¹, Kaoru Funabashi¹, Koichi Takahashi¹, Shuichi Ohkubo¹, Makoto Kitade¹ (1. Taiho Pharmaceutical Co., Ltd.)

医薬化学部会賞授賞式＆記念撮影 (2:00 PM - 2:10 PM)

2:10 PM - 2:40 PM

[S09-3] Discovery of delgocitinib as a novel JAK inhibitor

○Satoru Noji¹, Yoshinori Hara¹, Tomoya Miura¹, Hiroshi Yamanaka¹, Makoto Shiozaki¹ (1. JAPAN TOBACCO INC)

2:40 PM - 3:10 PM

[S09-4] The discovery of a novel siderophore cephalosporin Cefiderocol

○Toshiaki Aoki¹, Kenji Yamawaki², Takafumi Sato², Yasuhiro Nishitani², Yoshinori Yamano² (1. CMC R&D Division, SHIONOGI & CO., LTD., 2. Pharmaceutical Research Division, SHIONOGI & CO., LTD.)

まとめ：巾下広（小野薬品工業） (3:10 PM - 3:15 PM)