Oral Presentation

[27V08-pm] タンパク質・その他

Sat. Mar 27, 2021 3:15 PM - 5:51 PM [Room V08] Oral Presentation 8 (Online)

座長：伊藤昭博（東京薬大生命）、山下敦子（岡山大院医歯薬）

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3:15 PM - 3:27 PM

[27V08-pm10S] Suppression of in cellulo crystallization of neuraminidase 1 and application of gene therapy for NEU1 deficiency

○Jun Tsukimoto^1,3, Yuuto Horii¹, Toshiki Iniwa¹, Mizuki Miyoshi², So-ichiro Nishioka¹, Kohji Itoh^1,2,3 (1. Grad. Sch. of Pharmaceut. Sci., Tokushima Univ., 2. Facult. of Pharmaceut. Sci., Tokushima Univ., 3. AMED TR-SPRINT Seeds A)

3:27 PM - 3:39 PM

[27V08-pm11S] Molecular Charactarization of N-glycan-added CathepsinA for Treatment of Galactosialidosis

○Yuri Fukushi¹, Yuto Horii¹, Nodoka Nakamura¹, Takatsugu Hirokawa², Masayoshi Onitsuka³, Kohji Itoh¹ (1. Dept. of Medicin. Biotechnol., Grad. Sch. of Pharmaceut. Sci., Tokushima Univ., 2. Molprof. Res. Center. for Drug Discovery, AIST, 3. Dept. of Indust. and Soc. Sci., Grad. Sch. of Technol., Tokushima Univ.)

3:39 PM - 3:51 PM

[27V08-pm12S] Analysis of replacement effects of CHO-derived recombinant human CTSA precursor for enzyme replacement therapy of galactosialidosis.

○Yuto Horii¹, Koji Itoh¹ (1. Department of Medicinal Biotechnology, Graduate School of Pharmaceutical Sciences, Tokushima University)

3:51 PM - 4:03 PM

[27V08-pm13S] Replacement efficacy of human CTSA derived from TG silkworm cocoons on visceral organs in murine galactosialidosis model

○Yoshie Takeuchi¹, Hideki Sezutsu^3,5, Isao Kobayashi^3,5, Megumi Sumiya-Kasashima^3,5, Kenichiro Tatematsu^3,5, Tetsuya Iizuka^3,5, Takashi Kinoshita⁴, Ai Mitani⁴, Koji Itoh^1,2,5 (1. Facult. of Pharmacy, 2. Grad. Sch. of Pharmaceut. Sci, 3. NARO, 4. FUSHIMI Pharmaceut. Co. Ltd, 5. SeriRevo PT)

4:03 PM - 4:15 PM

[27V08-pm14] RNF2 ubiquitinates SBDS and promotes its degradation.

○Yukihiro Sera¹, Daichi Kajiyama¹, Kentaro Sugi¹, Shinji Matsuya¹, Takashi Ichinose¹, Miki Sadoya¹, Masafumi Yamaguchi¹ (1. Pharm. Sci., Hiroshima International Univ.)

4:15 PM - 4:27 PM

[27V08-pm15S] Elucidation of Molecular Mechanism of a Selective PPARα Modulator, Pemafibrate

○Akira Kambe¹, Mayu Kawasaki¹, Yuta Yamamoto², Sundaram Arulmozhiraja², Sohei Ito^1,4, Yoshimi Nakagawa^3,5,6, Hiroaki Tokiwa^2,4,7, Shogo Nakano^1,4, Hitoshi Shimano^4,5,6,8 (1. Grad. Sch. Int. Pharm. Nut. Sci., Univ. of Shizuoka, 2. Dep. Chem., Rikkyo Univ., 3. Inst. Nat. Med., Univ. of Toyama, 4. AMED-CREST, 5. Dep. Internal Med. Faculty of Med., Univ. of Tsukuba, 6. IIIS, 7. RCSM, 8. TARA)

4:27 PM - 4:39 PM

[27V08-pm16S] A novel p300-binding protein promoted hypertrophy in cultured cardiomyocytes

○Mizuki Unno¹, Yoichi Sunagawa^1,2,3, Yusaku Matsushita¹, Masafumi Funamoto^1,2, Kana Shimizu^1,2, Satoshi Shimizu^1,2, Yasufumi Katanasaka^1,2,3, Yusuke Miyazaki^1,2,3, Koji Hasegawa^1,2, Tatsuya Morimoto^1,2,3 (1. Pharmaceutical sciences, University of Shizuoka., 2. Kyoto Medical Center, National Hospital Organization. , 3. Shizuoka General Hospital.)

4:39 PM - 4:51 PM

[27V08-pm17S] Development of protease enrichment methods using cleaved substrate peptide probes

○Yuta Watanabe¹, Tomoya Niinae², Kosuke Ogata², Naoyuki Sugiyama², Yasushi Ishihama² (1. Faculty of Pharmaceutical Sciences, Kyoto University, 2. Graduate School of Pharmaceutical Sciences, Kyoto University)

4:51 PM - 5:03 PM

[27V08-pm18] Production and characterization of eggs form hens with targeted mutagenesis of ovomucoid gene using CRISPR/Cas9 system.

○Takehiro MUKAE¹, Kyoko Yoshii¹, Isao Oishi¹ (1. AIST Biomedical Research Institute)

5:03 PM - 5:15 PM

[27V08-pm19S] Experimental studies of the sequence dependence of Tailed Duplex, a tool for gene editing without artificial nucleases

○Ryotaro Kamitsubo¹, Kento Sato², Kentarou Yazama², Hidehiko Kawai^1,2, Hiroyuki Kamiya^1,2 (1. Sch. Pharm. Sci., Hiroshima Univ., 2. Grad. Sch. Biomed. Hlth. Sci., Hiroshima Univ.)

5:15 PM - 5:27 PM

[27V08-pm20S] Clarifying the mechanism of nuclear localization of RNA demethylase ALKBH5

○Tomomi Adachi¹, Kaori Kitae¹, Kentaro Jingushi¹, Hiroaki Hase¹, Kazutake Tsujikawa¹ (1. Mol. Cell. Physiol., Grad. Sch. Pharm., Osaka Univ.)

5:27 PM - 5:39 PM

[27V08-pm21S] Targeted RNA demethylation using sequence-specific RNA binding proteins

○Kenko Otonari¹, Shinoda Kouki¹, Miki Imanishi¹, Shiroh Futaki¹ (1. Institute for Chemical Research, Kyoto University)

5:39 PM - 5:51 PM

[27V08-pm22] Cell cycle specific mutation analysis resulting from CRISPR/Cas-induced DNA double strand breaks in human cells

○kazunari kondo¹, Nozomi Fukuda¹, Kozue Sakata¹, Taguchi chie¹, Junpei Narushima¹, Soga Keisuke¹ (1. National Institute of Health Sciences)

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