Oral Presentation

[27V09-pm] 薬効、薬物代謝、化学療法

Sat. Mar 27, 2021 1:15 PM - 3:27 PM [Room V09] Oral Presentation 9 (Online)

座長：天ヶ瀬紀久子（立命館大薬）、吉岡靖啓（摂南大薬）

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1:15 PM - 1:27 PM

[27V09-pm01S] Protective drugs against cardiotoxicity caused by doxorubicin using human iPS cell-derived cardiomyocytes

○Gen Igarashi¹, Momoka Nakagawa¹, Rin Watanabe¹, Toshihiko Yamaguchi¹, Makoto Inai¹, Toshiyuki Kan¹, Kazuho Sakamoto¹, Junko Kurokawa¹ (1. Sch. Pharmaceut. Sci, University of Shizuoka, Shizuoka, Japan)

1:27 PM - 1:39 PM

[27V09-pm02S] Elucidation of ACE2 expression control mechanism in aggravation of Covid-19 infection and search for new therapeutic agents

○Daiki Tomokiyo¹, Yuri Kato¹, Kazuhiro Nishiyama¹, Akiyuki Nishimura², Tomohiro Tanaka², Takahiro Kusakabe³, Noriho Kamiya⁴, Yumiko Imai⁵, Hiroshi Asakura⁶, Yasunari Kanda⁶, Motohiro Nishida^1,2 (1. Grad. Sch. Pharma Sci., Kyushu Univ., 2. Natl. Inst. Natul. Sci., 3. Grad. Sch. Agr., Kyushu Univ., 4. Grad. Sch. Eng., Kyushu Univ., 5. Natl. Inst. Biomed. Innov. Heal. Nutr., 6. Natl. Inst. Heal. Sci.)

1:39 PM - 1:51 PM

[27V09-pm03S] Discovery of HDAC inhibitory effect of Syrosingopine with Decomposition Profile Data Analysis

○Katsuhisa Morita¹, Tadahaya Mizuno¹, Hiroyuki Kusuhara¹ (1. Grad. Sch. Pharm. Sci., Univ of Tokyo.)

1:51 PM - 2:03 PM

[27V09-pm04] Identification of exosomal phospholipids as novel biomarkers for drug-induced liver injury

○Yuchen Sun¹, Kosuke Saito¹, Yoshiro Saito¹ (1. Dev. Med. Safety Sci., NIHS)

2:03 PM - 2:15 PM

[27V09-pm05S] Development of novel fluorescent labeled trapping reagent to detect reactive acyl glucuronides

○Chikako Shibazaki¹, Tomoyuki Ohe¹, Kyoko Takahashi¹, Shigeo Nakamura², Tadahiko Mashino¹ (1. Faculty of Pharmacy, Keio University, 2. Nippon Medical School)

2:15 PM - 2:27 PM

[27V09-pm06S] Metabolic ipso-Substitution of 5-Substituted-2-oxindole Catalyzed by Cytochrome P450

○Miki Kohei¹, Tomoyuki Ohe¹, Kyoko Takahashi¹, Shigeo Nakamura², Tadahiko Mashino¹ (1. Faculty of Pharmacy, Keio University, 2. Nippon Medical School)

2:27 PM - 2:39 PM

[27V09-pm07S] Identification of drug-metabolizing enzymes responsible for the metabolism of pirfenidone in the human liver

○Rei Sato¹, Tatsuki Fukami^1,2, Yongjie Zhang^2,3, Masataka Nakano^1,2, Miki Nakajima^1,2 (1. Faculty of Pharmaceutical Sciences, Kanazawa University, 2. WPI Nano Life Science Institute (WPI-NanoLSI), Kanazawa University, 3. Clinical Pharmacokinetics Laboratory, School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University)

2:39 PM - 2:51 PM

[27V09-pm08S] Generation and application of polydimethylsiloxane-based liver-on-a-chip for pharmacokinetic studies

○Sayaka Deguchi^1,2, Masahiro Tsuda³, Kaori Kosugi¹, Kazuya Maeda⁴, Hiroyuki Kusuhara⁴, Hiroyuki Mizuguchi^2,5, Fumiyoshi Yamashita³, Yu-suke Torisawa⁶, Kazuo Takayama¹ (1. CiRA, Kyoto Univ., 2. Grad. Sch. of Pharm. Sci., Osaka Univ., 3. Grad. Sch. of Pharm. Sci., Kyoto Univ., 4. Grad. Sch. of Pharm. Sci., The Univ. of Tokyo, 5. NIBIOHN, 6. Grad. Sch. of Eng., Kyoto Univ.)

2:51 PM - 3:03 PM

[27V09-pm09S] CDK8/c-MYC axis as a novel therapeutic target for glioblastoma

○Kazuya Fukasawa¹, Kazuya Tokumura¹, Sayuki Iwahashi¹, Takashi Iezaki¹, Eiichi Hinoi¹ (1. Lab. Pharmacol., Dept. Bioactive Molecules, Gifu Pharmaceutical Univ.)

3:03 PM - 3:15 PM

[27V09-pm10S] Combined effect of antibody-drug conjugate and DNA methylation inhibitor in malignant pleural mesothelioma

○TAKUMU YAMADA¹, YUI Shimizu¹, Kazunori Kato¹ (1. Grad.Sch.Sci.Eng,Toyo.Univ.)

3:15 PM - 3:27 PM

[27V09-pm11S] Analysis of antitumor effect of molecular-targeted drugs enhanced by nobiletin

○Kazuha Ito¹, Kazunori Kato¹ (1. Grad. Sch. Sci. Eng., Toyo Univ.)

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