Symposium

[GS03] Latest research on next-generation "neuro-immunology": multiangle approaches in the CNS and glia cells

Sun. Mar 28, 2021 1:15 PM - 3:15 PM [Room C] Oral Presentation C (Online)

Organizer: Yoshida Sara (Hoshi Univ.), Kohno Keita (Grad. Sch. Pharmaceut. Sci. Kyushu. Univ.)

In general, various external stimuli associated with excess stress and chronic pain induce synaptic plasticity and dysfunction of both the central nervous system (CNS) and glial cells (astrocytes and microglia). Abnormality of the neural network and/or glial cells triggers various disease-based phenotypes, such as psychiatric disorders, persistent pain, dementia and immunodeficiency. On the other hand, it has been suggested that dysfunction of the CNS leads to peripheral symptoms through various efferent controls. However, the causal relationship between synaptic plasticity and peripheral phenomena, such as chronic pain and immunodeficiency, has not yet been clarified. To investigate these mechanisms, it is crucial that we understand “neuro-immunity” mediated by neural and glial functions. In this symposium, we will introduce the latest research on “neuro-immunity” derived from dysfunction of the CNS and glial cells, which is associated with various diseases. We hope that our discussions will provide the audience insights that could lead to the discovery of new treatments.

+Add all to schedule

オーガナイザー挨拶：吉田小莉（星薬大） (1:15 PM - 1:20 PM)

1:20 PM - 1:42 PM

[GS03-1] Pathological mechanism of autoimmune encephalomyelitis regulated by vagus nerve innervation

○Steve So Mansfield^1,2, Shogo Tanabe¹, Rieko Muramatsu¹ (1. NCNP, 2. Tokyo Med. & Dent. Univ. Grad. Sch. Med. & Dent. Sci.)

1:42 PM - 2:04 PM

[GS03-2] Single-nucleus RNA sequencing unravels distinct cellular repair responses in adult and neonatal mice after spinal cord injury.

○Iyo Yorifuji¹, Hiroshi Tsujioka¹, Yasushi Sakata¹, Toshihide Yamashita¹ (1. Osaka Univ. Medicine)

2:04 PM - 2:26 PM

[GS03-3] Role of a microglia subset in neuropathic pain

○Keita Kohno¹, Makoto Tsuda¹ (1. Grad. Sch. Pharmaceut. Sci. Kyushu. Univ.)

2:26 PM - 2:48 PM

[GS03-4] Subtype-specific dynamics and roles for chronic stress-induced mobilization of leukocytes

○Yuka Ishikawa^1,2, Shiho Kitaoka¹, Taro Kato², Tomoyuki Furuyashiki¹ (1. Grad. Sch. of Med., Kobe Univ., 2. Sumitomo Dainippon Pharm)

2:48 PM - 3:10 PM

[GS03-5] The cancer immune system is efferently controlled by the central nervous system.

○Sara Yoshida¹, Yusuke Hamada^1,4, Shuhei Yabe¹, Daisuke Sato¹, Michiko Narita^2,4, Akihiro Yamanaka³, Naoko Kuzumaki¹, Minoru Narita^1,4 (1. Hoshi Univ., 2. IMS, Tokyo Med. Univ., 3. RIEM, Nagoya Univ., 4. NCCRI)

総括：河野敬太（九大院薬） (3:10 PM - 3:15 PM)

Session information