Symposium

[S16] The symposium organized by Division of Pharmaceutical Health Sciences and Environmental Toxicology: Mechanisms of physiological adaptation to various types of stress and the regulation of diseases

Sun. Mar 28, 2021 9:30 AM - 11:30 AM [Room E] Oral Presentation E (Online)

Organizer: Matsuzawa Atsushi (Grad. Sch. Pharmaceut. Sci., Tohoku Univ.), Imai Hirotaka (Sch. Pharm. Sci., Kitasato Univ.)

Living organisms and cells are constantly exposed to various types of stress. Meanwhile, they adapt to the external and internal environment and maintain biological functions and homeostasis, through the appropriate responses to and elimination of the stress. The living body has elaborate mechanisms for adapting to various types of stress, and the failure of the mechanisms causes various diseases and physiological disorders induced by toxic substances. Therefore, the understanding of the mechanisms for adapting to the stress leads to the regulation of and therapeutic strategies for various diseases. In this symposium, we focus on the mechanisms of physiological adaptation to a variety of stress, such as oxidative stress, toxic chemicals-induced stress, and stress caused by cell death or dysregulation of lipid metabolism. Each symposiast introduces the novel mechanisms of physiological adaptation to a variety of stress, and discusses how the failure of the adaptation mechanisms results in the onset of various diseases and the development of physiological disorders induced by toxic substances.

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オーガナイザー挨拶：松沢厚（東北大院薬） (9:30 AM - 9:32 AM)

9:32 AM - 9:55 AM

[S16-1] Change of lysosomal enzymes in model cells of diseases

○Yaichiro Kotake¹, Masatsugu Miyara^1,2 (1. Grad. Sch. of Biomed. Sci., Hiroshima Univ., 2. Gifu Pharm. Univ.)

9:55 AM - 10:18 AM

[S16-2] Novel stress-induced cell death and the regulation of diseases

○Atsushi Matsuzawa¹ (1. Grad. Sch. Pharmaceut. Sci., Tohoku Univ.)

10:18 AM - 10:41 AM

[S16-3] Nrf2 suppresses oxidative stress and inflammation in App knock-in Alzheimer's disease model mice

○Daisuke Matsumaru¹, Akira Uruno^2,3, Rie Ryoke⁴, Ritsumi Saito^2,3, Shiori Kadoguchi², Daisuke Saigusa^2,3, Takashi Saito⁵, Takaomi Saido⁶, Ryuta Kawashima⁴, Masayuki Yamamoto^1,3 (1. Gifu Pharm. Univ., 2. Grad. Sch. Med., Tohoku Univ., 3. ToMMo, Tohoku Univ., 4. IDAC, Tohoku Univ., 5. Grad. Sch. Med., Nagoya City Univ., 6. RIKEN CBS.)

10:41 AM - 11:04 AM

[S16-4] Mechanisms of oxidative stress response via integrated stress response

○Shusuke Kuge¹, Kouki Takeda¹, Kenta Iwai^1,2, Atsushi Inose (Maruyama)^1,3, Hayato Irokawa¹ (1. Tohoku Med. Pharm. Univ. Fac. Pharm., 2. NIES, 3. Nihon Pharm. Univ.)

11:04 AM - 11:27 AM

[S16-5] Analysis of mechanism of GPx4 loss induced human disease using GPx4 KO model mice

○Hirotaka Imai¹ (1. Sch. Pharm. Sci., Kitasato Univ.)

総括：今井浩孝（北里大薬） (11:27 AM - 11:30 AM)

Session information