[29V02-am] 核酸①

Mon. Mar 29, 2021 9:00 AM - 10:24 AM [Room V02] Oral Presentation 2 (Online)

座長：今井信行（千葉科学大薬）、原田慎吾（千葉大院薬）

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9:00 AM - 9:12 AM

[29V02-am01S] Synthesis and properties of 2'-O,4'-C-spirocyclopentylene bridged nucleic acid

○Takaya Sugiura¹, Hibiki Komine¹, Takao Yamaguchi¹, Satoshi Obika¹ (1. Grad. Sch. Pharm. Sci., Osaka Univ.)

9:12 AM - 9:24 AM

[29V02-am02S] Evaluation of Novel Bridged Nucleic Acids Bearing a Hydrophobic Substituent Group Focusing on the Hydrophobic Interactions with Minor Groove

○Ryusuke Hatanaka¹, Naohiro Horie¹, Takao Yamaguchi¹, Satoshi Obika¹ (1. Grad. Sch. Pharm. Sci., Osaka Univ.)

9:24 AM - 9:36 AM

[29V02-am03S] Synthesis and evaluation of 1'-C,3'-O-propylene-bridged altriol nucleic acid

○Chika Yamamoto¹, Yota Sakurai¹, Takao Yamaguchi¹, Satoshi Obika¹ (1. Grad. Sch. Pharm. Sci., Osaka Univ.)

9:36 AM - 9:48 AM

[29V02-am04S] Synthesis and evaluation of lipid-modified antisense oligonucleotides

○Yuya Tanaka¹, Yurika Tanioku¹, Kotomi Aso¹, Taisuke Nakayama², Haruhiko Kamada², Takao Yamaguchi¹, Satoshi Obika¹ (1. Grad. Sch. Pharm. Sci., Osaka Univ., 2. NIBIOHN)

9:48 AM - 10:00 AM

[29V02-am05S] Selection of anti-beta-catenin base-modified aptamers have cell-internalization ability.

○Keisuke Tanaka^1,2, Takumi Okuda^1,2, Yuuya Kasahara^1,2, Satoshi Obika^1,2 (1. Grad. Sci. Pharm. Sci., Osaka Univ., 2. NIBIOHN)

10:00 AM - 10:12 AM

[29V02-am06] Synthesis of dual modified nucleic acid for generating aptamers with high in vivo stability and affinity

○Kenta Ishida¹, Yuuya Kasahara^1,2, Hidekazu Hoshino¹, Satoshi Obika^1,2 (1. NIBIOHN, 2. Grad. Sch. Pharm. Sci. Osaka Univ.)

10:12 AM - 10:24 AM

[29V02-am07] Discovery of indole-modified aptamers targeting lung fibroblasts with cellular internalization activity

○Hiro Uemachi^1,2,3, Keisuke Tanaka^1,2, Takumi Okuda^1,2, Yuuya Kasahara^1,2, Yoshihiro Yoneda², Satoshi Obika^1,2 (1. Grad. Sch. Pharma. Sci., Osaka Univ., 2. NIBIOHN, 3. Sumitomo Dainippon Pharma)

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