[29V08-pm] ADMET, PK/PD③/薬物間相互作用/その他

Mon. Mar 29, 2021 1:15 PM - 3:15 PM [Room V08] Oral Presentation 8 (Online)

座長：井上勝央（東京薬大）、小柳悟（九大院薬）

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1:15 PM - 1:27 PM

[29V08-pm01] Identification of metabolic capacity-limited drugs using chemical structures.

○Yusuke Kan^1,2, Yoshihiro Uesawa¹ (1. Meiji Pharm. Univ., 2. Nanohana Pharmacy akishimaekimaeten)

1:27 PM - 1:39 PM

[29V08-pm02] Application of human biopsy-derived duodenal organoids for pharmacokinetic studies

○Tomoki Yamashita¹, Tatsuya Inui¹, Jumpei Yokota¹, Kentaro Kawakami^2,3, Daisuke Hirayama³, Ryuga Nomoto¹, Wataru Kishimoto⁴, Hiroshi Nakase³, Hiroyuki Mizuguchi^1,5,6,7 (1. Grad. Sch. Pharmaceutical Sci., Osaka Univ., 2. Keiyukai Sapporo Hospital, 3. Sapporo Med. Univ., 4. Nippon Boehringer Ingelheim, 5. NIBIOHN, 6. MEI Center, Osaka Univ., 7. OTRI, Osaka Univ.)

1:39 PM - 1:51 PM

[29V08-pm03S] Development of prodrug to avoid chelate formation between quinolone agent and metal cation -Levofloxacin Cilexetil ester-

○Takato Maeda¹, Yuka Takahashi¹, Yuki Naika¹, Yuzho Hieda¹, Takeshi Goroumaru¹, Seiji Eto¹, Yorinobu Maeda¹ (1. Laboratory of Drug Information Analytics ,Faculty of Pharmacy & Pharmaceutic Sci.,Fukuyama Univ.)

1:51 PM - 2:03 PM

[29V08-pm04] Mechanism underlying infusion-site adverse events induced by anthracycline and fosaprepitant

○Keisuke Oda¹, Haruka Yamashiro¹, Rami Gogatsubo¹, Miho Yamasaki², Kei Omoda², Yorinobu Maeda³, Nobuhiro Mori¹ (1. Fac. Pharm. Sci., Hiroshima Int. Univ., 2. Chugoku Rosai Hosp. , 3. Fac. Pharmacy Pharm. Sci.,Fukuyama Univ.)

2:03 PM - 2:15 PM

[29V08-pm05S] Evaluation of variety and affinity of the antibodies induced by spleen immunization with antigen-encapsulating liposomes

○Sesshu Yamaguchi¹, Hidenori Ando¹, Yuna Shimazaki¹, Taro Shimizu¹, Yu Ishima¹, Tatsuhiro Ishida¹ (1. Grad. Sch. Biomed. Sci., Tokushima Univ.)

2:15 PM - 2:27 PM

[29V08-pm06S] Evaluation of binding potency of antibodies induced by spleen immunization with exosomes

○Reon Kuramoto¹, Hidenori Ando¹, Taro Shimizu¹, Yu Ishima¹, Tatsuhiro Ishida¹ (1. Grad. Sch. Biomed. Sci., Tokushima Univ.)

2:27 PM - 2:39 PM

[29V08-pm07S] Development of allergic rhinitis immunotherapy using antigen-loaded multifunctional small extracellular vesicles (sEVs)

○Wen Liu¹, Maki Ota¹, Yuki Takahashi¹, Yusuke Kawamoto¹, Yoshinobu Takakura¹ (1. Grad. Sch. Pharm., Kyoto Univ)

2:39 PM - 2:51 PM

[29V08-pm08S] Vinblastine enhances the intestinal functions and decreases the undifferentiated cell contamination of human iPS cell-derived intestinal epithelial-like cells

○Moe Ichikawa¹, Ryosuke Negoro¹, Kanae Kawai^2,5, Kazuo Takayama^1,2, Hiroyuki Mizuguchi^1,2,3,4,5 (1. Laboratory of Biochemistry and Molecular Biology, Graduate School of Pharmaceutical Sciences, Osaka University, 2. Laboratory of Biochemistry and Molecular Biology, School of Pharmaceutical Sciences, Osaka University, 3. Laboratory of Global Center for Medical Engineering and Informatics, Osaka University, 4. Integrated Frontier Research for Medical Science Division, Institute for Open and Transdisciplinary Research Initiatives (OTRI), Osaka University, 5. Hepatocyte Regulation, National Institutes of Biomedical Innovation, Health and Nutrition)

2:51 PM - 3:03 PM

[29V08-pm09S] Comparison of human biopsy-derived and human iPS cell-derived intestinal organoids from the same individual

○Tatsuya Inui¹, Tomoki Yamasita¹, Ryuga Nomoto¹, Jumpei Yokota¹, Kentaro Kawakami^2,3, Wataru Kishimoto⁵, Hiroshi Nakase², Hiroyuki Mizuguchi^1,4,6,7 (1. Grad. Sch. of Pharm. Sci, Osaka Univ., 2. Sch. of Med., Sapporo Med. Univ., 3. Keiyukai Sapporo Hosp., 4. NIBIOHN, 5. Nippon Boehringer Ingelheim Co., Ltd., 6. MEI cent., Osaka Univ., 7. OTRI, Osaka Univ.)

3:03 PM - 3:15 PM

[29V08-pm10S] Comparison of human intestinal organoid culture methods for pharmacokinetic applications

○Jumpei Yokota¹, Tomoki Yamashita¹, Tatsuya Inui¹, Ryuga Nomoto¹, Kentaro Kawakami^2,5, Wataru Kishimoto⁴, Hiroshi Nakase⁵, Hiroyuki Mizuguchi^1,3,6,7 (1. Grad. Sch. of Pharm. Sci, Osaka Univ., 2. Keiyukai Sapporo Hosp., 3. NIBIOHN, 4. Nippon Boehringer Ingelheim Co., Ltd., 5. Sch. of Med., Sapporo Med. Univ., 6. MEI cent., Osaka Univ., 7. OTRI, Osaka Univ.)

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