The second generation antipsychotic olanzapine induces atypical development of diabetes due to aberrant disulfide bond formations of proinsulin in pancreatic beta cells

○Satoshi Ninagawa

9:24 AM - 9:36 AM

[29V05-am03] The second generation antipsychotic olanzapine induces atypical development of diabetes due to aberrant disulfide bond formations of proinsulin in pancreatic beta cells

○Satoshi Ninagawa¹, S Tada², M Okumura³, K Inoguchi², M Kinoshita³, S Kanemura⁴, K Imami⁵, H Umezawa¹, T Ishikawa¹, R Mackin⁶, S Torii⁷, Y Ishihama⁵, K Inaba⁸, T Anazawa², T Nagamine⁹, K Mori¹ (1. Grad. Sch. Sci., Kyoto Univ., 2. Grad. Sch. Med., Kyoto Univ., 3. Front. Res. Inst. Inter. Sci., Tohoku Univ. , 4. Sch. Sci. & Tec., Kwansei Gakuin Univ., 5. Grad. Sch. Pharma. Sci., Kyoto Univ., 6. Dep. Bio. Sci., Creighton Univ., 7. Inst. Mol. Cell. Regu., Gunma Univ., 8. Inst. Multidis. Res. Adv. Materi., Tohoku Univ., 9. Sunl. Brain Res. Cent.)

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[29V05-am] タンパク質分解・ストレス応答

[29V05-am03] The second generation antipsychotic olanzapine induces atypical development of diabetes due to aberrant disulfide bond formations of proinsulin in pancreatic beta cells

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