Workshop

[WS10] Dynamic-Allosteric regulation molecular mechanism of multi-specific function of proteins in cell system

Fri. Jun 18, 2021 9:45 AM - 12:15 PM Channel 3

Organizers: Yasushige Yonezawa (Kindai Univ.), Yuko Tsuchiya (AIST)

Proteins regulate cell system in a very sophisticated manner. The mechanisms that realize this exquisite control have not yet been elucidated. Proteins are dynamic entities, and it is difficult to understand the diversity, specificity, and cooperativity from static view point. Here, we would like to review and discuss the experimental and theoretical studies on the dynamic and allosteric properties that exhibit diverse multi-specific functions of proteins.

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9:45 AM - 10:10 AM

[WS10-01] Autoencoder-based detection of the residues involved in GPCR signaling

^○Yuko Tsuchiya¹, Kei Taneishi², Yasushige Yonezawa³ (1.AIRC, AIST, 2.RIKEN, 3.KINDAI Univ.)

10:10 AM - 10:35 AM

[WS10-02(3P-30)] Cryo-EM structure of human prostaglandin E2 receptor EP3-G protein complex

^○Ryoji Suno¹, Yukihiko Sugita², Kazushi Morimoto³, Hirokazu Tsujimoto³, Mika Hirose⁴, Chiyo Suno¹, Norimichi Nomura³, Kenji Iwasaki⁵, Takayuki Kato³, So Iwata³, Takuya Kobayashi¹ (1.Med., KMU, 2.IVR, Kyoto Univ., 3.Med, Kyoto Univ., 4.IPR, Osaka Univ., 5.TARA)

10:35 AM - 11:00 AM

[WS10-03] Fluctuation and Variation in biology

^○Takuma Shiraki (Kindai Univ. BOST)

11:00 AM - 11:25 AM

[WS10-04(3P-31)] Structural characterization of dynamic changes of histone H3 N-tails through FACT using synergistic structural biology approaches

^○Yasuo Tsunaka¹, Hideaki Ohtomo¹, Kosuke Morikawa², Yoshifumi Nishimura^1,3 (1.Grad. Sch. of Med. Life Sci., Yokohama City Univ., 2.Grad. Sch. of Biostudies, Kyoto Univ., 3.Grad. Sch. of Int. Sci. Life, Hiroshima Univ.)

11:25 AM - 11:50 AM

[WS10-05] Correlation analysis of the protein environment around heme and the heme distortion in hemeproteins

^○Hiroko X. Kondo¹, Hiroyuki Iizuka², Gen Masumoto³, Yusuke Kanematsu⁴, Yu Takano⁵ (1.Fac. Eng., Kitami Inst.Tech., 2.Grad. Sch. Info. Sci. Tech., Hokkaido Univ., 3.Info. Sys. Div, RIKEN ISC, 4.Grad. Shc. Adv. Sci. Eng., Hiroshima Univ., 5.Grad. Sch. Info. Sci, Hiroshima City Univ.)

11:50 AM - 12:15 PM

[WS10-06] Difficulties and New Challenges in Dynamic Correlation Analysis of Proteins and Protein Complexes Using Computational Science Simulation

^○Yasushige Yonezawa (Inst. Adv. Tech. of Kindai)