[3P-1] Poster 3 (3P-01ー3P-47)

[3P-37] Database analysis of protein-protein interactions

^○Wataru Sagawa, George Chikenji (Dept. of App. Phys., Nagoya Univ.)

Protein-Protein Interaction (PPI) is important for molecular functions in biology. Understanding its mechanism is needed to design proteins that interact with other proteins. To gain deeper understanding of PPI, we performed a database analysis of PPI. In particular, unlike many researches of database analysis of PPI, which focus on preferred contact pairs, we focused on the composition of PPI members. We performed hierarchical clustering for interfaces of protein complexes and found that these are classified into only a limited number of patterns. The composition of amino acid constituting the interface largely differs depending on the pattern. In the presentation, we will provide detail data and discuss how our results are useful for designing protein binder.