4:45 PM - 6:45 PM

[1P0388] Crystal structure of trypanosome alternative oxidase (TAO) in complex with two different types of inhibitor: ascofuranone and ferulenol.

〇Satoshi Ueda¹, Machi Nakai¹, Tomoo Shiba¹, Gen Takahashi¹, Daniel K Inaoka², Yasutoshi Kido², Kimitoshi Sakamoto², Tiaki Tsuge², Emmanuel Oluwadare Balogun², Takeshi Nara³, Takashi Aoki³, Mitsutaka Honma⁴, Akiko Tanaka⁴, Masayuki Inoue⁵, Shigeru Matsuoka⁵, Moore L. Anthony⁶, Hiroyuki Saimoto⁷, Shigeharu Harada¹, Kiyoshi Kita² (1.Dept. Appl. Biol., Grad. Sch. Sci. and Tech., Kyoto Institute of Technology, 2.Dept. Biomed. Chem., Grad. Sch. Med., The University of Tokyo, 3.Dept. Mol. Cell Parasitol., Sch. Med. Juntendo Univ., 4.Sys. Struc. Biol. Center, RIKEN, 5.Grad. Sch. Pharm. Sci., Univ. of Tokyo, 6.Biochem. Biomed. Sci., Sch. of Life Sci., Univ. of Sussex, 7.Dept. Materials Sci., Grad. Sch. Eng., Tottori Univ.)

Alternative Oxidase, Trypanosoma, Crystal structure, drug design