4:45 PM - 6:45 PM

[1P1350] Mitochondrial function provides instructive signals for activation-induced B cell　fates

〇Kyoungjin Jang¹, Hiroto Mano¹, Koji Aoki², Tatsunari Hayashi¹, Akihiko Muto³, Yukiko Nambu^1,6, Katsu Takahashi¹, Katsuhiko Itoh¹, Shigeru Taketani⁴, Stephen L. Nutt⁵, Kazuhiko Igarashi³, Akira Shimizu¹, Manabu Sugai^1,2 (1.Dept. of Exp. Thera., Ins. for Ad. of Cli. and Trans. Sci., Kyoto Univ., 2.Div. of Phar., Sch. of Med., Univ. of Fukui, 3.Dep. of Biochem., Tohoku Univ. Grad. Sch. of Med., 4.Dept. of Biotech., Kyoto Ins. of Tech., 5.The Walter and Eliza Hall Ins. of Med. Res., Melbourne, 6.Bioprocessing Techn. Ins., A*STAR20 Biopolis)

Class-switch recombination, Plasma-cell differentiation, Mitochondrial reactive oxygen species, Heme homeostasis