Receptor-type protein tyrosine phosphatase PTPRK attenuates CD133-mediated tumorigenesis of colon cancer cells through the down-regulation of pro-oncogenic CD133-PI3K-AKT pathway.

Masashi Matsushita; Osamu Shimozato; Hiroaki Soda; Kyosuke Uchiumi; Mizuyo Nakamura; Takehiro Ogata; Toshinori Ozaki

4:45 PM - 6:45 PM

[2LBA046] Receptor-type protein tyrosine phosphatase PTPRK attenuates CD133-mediated tumorigenesis of colon cancer cells through the down-regulation of pro-oncogenic CD133-PI3K-AKT pathway.

〇Masashi Matsushita¹, Osamu Shimozato¹, Hiroaki Soda², Kyosuke Uchiumi¹, Mizuyo Nakamura¹, Takehiro Ogata¹, Toshinori Ozaki¹ (1.Lab. of DNA Damage Signaling, Chiba Cancer Ctr. Res. Inst., 2.Dep. of Gastrointestinal Surgery, Chiba Cancer Ctr. Hospital.)

Cancer stem cell, Protein tyrosine phosphatase, CD133, PTPRK, Tumorigenesis

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BMB2015 Biochemistry and Molecular Biology

[2LBA046] Receptor-type protein tyrosine phosphatase PTPRK attenuates CD133-mediated tumorigenesis of colon cancer cells through the down-regulation of pro-oncogenic CD133-PI3K-AKT pathway.

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