4:45 PM - 6:45 PM

[2P1282] Sustained activation of CaMKII mediates neurodegeneration caused by depletion of axonal mitochondria

〇Mikiko Oka¹, Akiko Maruko-Otake², Yosuke Ohtake³, Naoya Yamaguchi⁴, Michiko Sekiya⁵, Koichi M. Iijima⁵, Kanae Ando^1,4 (1.Department of Biological Sciences, Graduate School of Science and Engineering, Tokyo Metropolitan University, 2.Department of Neuroscience, Thomas Jefferson University, Philadelphia, PA, USA, 3.Shriners Hospitals Pediatric Research Center, Temple University School of Medicine, Philadelphia, PA, USA, 4.Department of Biological Sciences, Graduate School of Science and Engineering, Tokyo Metropolitan University, 5.Department of Alzheimer Disease Research, National Center for Geriatrics and Gerontology, Obu, Aichi, Japan)

Drosophila, mitochondria, neurodegeneration, Ca2+/calmodulin-dependent protein kinase II, presynaptic terminals