4:45 PM - 6:45 PM

[2P1283] Sustained activation of CaMKII mediates enhancement of tau toxicity caused by depletion of mitochondria from the axon

〇Motoki Hayashishita¹, Akiko Maruko-Otake², Yosuke Ohtake³, Michiko Sekiya⁴, Koichi M. Iijima⁴, Kanae Ando^1,5 (1.Department of Biological Sciences, Graduate School of Science and Engineering, Tokyo Metropolitan University, 2.Department of Neuroscience, Thomas Jefferson University, Philadelphia, PA, USA, 3.Shriners Hospitals Pediatric Research Center, Temple University School of Medicine, Philadelphia, PA, USA, 4.Department of Alzheimer Disease Research, National Center for Geriatrics and Gerontology, Obu, Aichi, Japan, 5.Department of Biological Sciences, Graduate School of Science and Engineering, Tokyo Metropolitan University)

tau, phosphorylation, mitochondria, Drosophila model of neurodegenerative diseases, Ca2+/calmodulin-dependent protein kinase II