3:40 PM - 3:50 PM

[2T特p-11(2P1160)] High-affinity, poly-reactive IgA is required for gut homeostatic maintenance to prevent colitis in mice.

〇Shinsaku Okai¹, Fumihito Usui¹, Makoto Hasegawa¹, Toshinobu Nakamura², Kazuya Yamamoto³, Eri Nishiyama³, Hiroshi Mori³, Takuji Yamada³, Ken Kurokawa⁴, Tamotsu Kato⁵, Eiji Miyauchi⁵, Hiroshi Ohno^5,6,7,8, Reiko Shinkura^1,9 (1.Department of Immunology, Nagahama Institute of Bioscience and Technology, 2.Department of Epigenetics, Nagahama Institute of Bioscience and Technology, 3.Graduate School of Bioscience and Biotechnology,Tokyo Institute of Technology, 4.Earth-Life Science Institute,Tokyo Institute of Technology, 5.RIKEN Center for Integrative Medical Sciences (IMS), 6.Graduate School of Medicine, Chiba University, 7.Graduate School of Medical Life Science, Yokohama City University, 8.AMED-CREST, 9.PRESTO)