4:45 PM - 6:45 PM

[3P0326(3T17-15)] Crystal structure of human Keap1 in complex with a small molecule and structural evaluation using molecular dynamics simulation

Mikiya Satoh^1,2, Hajime Saburi^1,2, Tomoyuki Tanaka¹, Yoshinori Matsuura¹, Hisashi Naitow¹, Rieko Shimozono², Naoyoshi Yamamoto², Hideki Inoue², Noriko Nakamura², Yoshitaka Yoshizawa², Takumi Aoki², Ryuji Tanimura², 〇Naoki Kunishima¹ (1.RIKEN SPring-8 Center, 2.Pharmaceutical Research Laboratories, Toray)

oxidative stress, antioxidant response, beta-propeller, crystal packing, fragment-based drug discovery