4:45 PM - 6:45 PM

[3P0437(4T10L-01)] Functional characterization of mitochondrial malate:quinone oxidoreductase from Plasmodium falciparum and identification of nanomolar order inhibitors

〇Russell J Miller¹, Daniel K Inaoka¹, Kuroda Marie¹, Balogun O Emmanuel^1,2, Eri Amalia¹, Hiroyuki Saimoto³, Keisuke Komatsuya¹, Yohichi Watanabe¹, Dan Sato⁴, Tomo Nozaki⁵, Tomoo Shiba⁴, Shigeharu Harada⁴, Kiyoshi Kita¹ (1.Department of Biomedical Chemistry, Graduate School of Medicine, The University of Tokyo, 2.Department of Biochemistry, Ahmadu Bello University, 3.Department of Chemistry and Biotechnology, Graduate School of Engineering, Tottori University, 4.Department of Applied Biology, Graduate School of Science and Technology, Kyoto Institute of Technology, 5.Department of Parasitology, National Institute of Infectious Diseases)

Malaria, Drug Discovery, Mitochondria, Electron Transport Chain, Inhibitor Optimization