The Japanese Biochemical Society/The Molecular Biology Society of Japan

4:45 PM - 6:45 PM

[3P1112] Anti-tumor efficacy and preferential localization of KR12, KRAS mutation specific alkylating agent in KRAS mutant xenografts with little to no adverse effects

〇Takahiro Inoue1, Kiriko Hiraoka1, Hiroyuki Yoda1, Takayoshi Watanabe1, Atsushi Takatori1, Nobuko Koshikawa1, Shigeharu Wakana3, Toshikazu Bando4, Hiroshi Sugiyama4, Toshinori Ozaki2, Hiroki Nagase1 (1.Lab. Cancer Genetics, Chiba Cancer Centr. Res. Inst., 2.Lab. DNA Damage Signaling, Chiba Cancer Centr Res. Inst., 3.Japan Mouse Clinic, RIKEN BRC, 4.Dep. Chem., Grad. Sch. Sci., Univ. Kyoto)

pyrrole-imidazole polyamide, KRAS, in vivo

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