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[3P1182(4T特-06)] Inhibition of the Oxygen Sensor PHD2 in the Liver Improves Survival in Lactic Acidosis by Activating the Cori Cycle

〇Tomohiro Suhara1,2, Takako Hishiki1,3,4,5, Masataka Kasahara1,6, Noriyo Hayakawa1,3,4, Tomoko Oyaizu1,2, Tsuyoshi Nakanishi1,7, Akiko Kubo1,4, Hiroshi Morisaki2, William G. Kaelin Jr.8,9, Makoto Suematsu1,4, Yoji A. Minamishima1,4 (1.Dept. of Biochem., Keio Univ. Sch. of Med., 2.Dept. of Anesth., Keio Univ. Sch. of Med., 3.Dept. of TR Center., Keio Univ. Sch. of Med., 4.JST-ERATO Suematsu Gas Biology Project, 5.JST-CREST, 6.Dept. of Pharm., Tokyo Dental College, 7.MS Business Unit, Shimadzu Corporation, 8.Dept. of Med. Onc., Dana-Farber Cancer Inst. and Brigham and Women's Hosp., Harvard Med. Sch., Boston, 9.Howard Hughes Med. Inst., Chevy Chase, Maryland)

Hypoxic response, HIF, PHD, Cori cycle, Lactic acidosis

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