4:45 PM - 6:45 PM

[3P1182(4T特-06)] Inhibition of the Oxygen Sensor PHD2 in the Liver Improves Survival in Lactic Acidosis by Activating the Cori Cycle

〇Tomohiro Suhara^1,2, Takako Hishiki^1,3,4,5, Masataka Kasahara^1,6, Noriyo Hayakawa^1,3,4, Tomoko Oyaizu^1,2, Tsuyoshi Nakanishi^1,7, Akiko Kubo^1,4, Hiroshi Morisaki², William G. Kaelin Jr.^8,9, Makoto Suematsu^1,4, Yoji A. Minamishima^1,4 (1.Dept. of Biochem., Keio Univ. Sch. of Med., 2.Dept. of Anesth., Keio Univ. Sch. of Med., 3.Dept. of TR Center., Keio Univ. Sch. of Med., 4.JST-ERATO Suematsu Gas Biology Project, 5.JST-CREST, 6.Dept. of Pharm., Tokyo Dental College, 7.MS Business Unit, Shimadzu Corporation, 8.Dept. of Med. Onc., Dana-Farber Cancer Inst. and Brigham and Women's Hosp., Harvard Med. Sch., Boston, 9.Howard Hughes Med. Inst., Chevy Chase, Maryland)

Hypoxic response, HIF, PHD, Cori cycle, Lactic acidosis