The Japanese Biochemical Society/The Molecular Biology Society of Japan

BMB2015 Biochemistry and Molecular Biology

BMB2015 Biochemistry and Molecular Biology

Dec 1, 2015 - Dec 4, 2015
Kobe Port Island

4:45 PM - 6:45 PM

[3P1231(4T15L-01)] Loss of p62/SQSTM1 but not Nrf2 accelerates motor neuron degeneration in SOD1H46R transgenic mice

〇Shun Mitsui1, Mizuki Kubo1, Lei Pan1, Asako Otomo1, Masato Koike2, Yasuo Uchiyama2, Masashi Aoki3, Masayuki Yamamoto4, Tetsuro Ishii5, Toru Yanagawa5, Hui-Fang Shang6, Fumihito Yoshii7, Shinji Hadano1 (1.Dept Mol Life Sci, Tokai Univ Sch of Med, 2.Dept Cell Biol & Neurosci, Juntendo Univ Grad Sch of Med, 3.Dept Neurol, Tohoku Univ Grade Sch of Med, 4.Dept Med Biochem, Tohoku Univ Grade Sch of Med, 5.Facul Med, Univ of Tsukuba, 6.West China Hosp Sichuan Univ, China, 7.Dept Neurol, Tokai Univ Sch of Med)

ALS, 筋萎縮性側索硬化症, p62/SQSTM1, オートファジー

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