RNA and nucleolar localization prevents toxicity and aggregation of carboxyl-terminal fragment of ALS-linked TDP43 via inhibition of the structural transition in Prion-like domain.

Akira Kitamura; Yusaku Nakayama; Ai Shibasaki; Ayami Taki; Sachiko Yuno; Masataka Kinjo

4:45 PM - 6:45 PM

[3P1233(4T15L-03)] RNA and nucleolar localization prevents toxicity and aggregation of carboxyl-terminal fragment of ALS-linked TDP43 via inhibition of the structural transition in Prion-like domain.

〇Akira Kitamura^1,2, Yusaku Nakayama², Ai Shibasaki², Ayami Taki², Sachiko Yuno², Masataka Kinjo^1,2 (1.Lab. of Mol. Cell Dyn., Fac. Adv. Life Sci., Hokkaido Univ., 2.Grad. Sch. of Life Sci., Hokkaido Univ.)

TDP43, RNA-binding protein, Prion, protein aggregation, Spectroscopic live-cell imaging

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BMB2015 Biochemistry and Molecular Biology

[3P1233(4T15L-03)] RNA and nucleolar localization prevents toxicity and aggregation of carboxyl-terminal fragment of ALS-linked TDP43 via inhibition of the structural transition in Prion-like domain.

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