The Japanese Biochemical Society/The Molecular Biology Society of Japan

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[4T10L-01(3P0437)] Functional characterization of mitochondrial malate:quinone oxidoreductase from Plasmodium falciparum and identification of nanomolar order inhibitors

〇Russell J Miller1, Daniel K Inaoka1, Kuroda Marie1, Balogun O Emmanuel1,2, Eri Amalia1, Hiroyuki Saimoto3, Keisuke Komatsuya1, Yohichi Watanabe1, Dan Sato4, Tomo Nozaki5, Tomoo Shiba4, Shigeharu Harada4, Kiyoshi Kita1 (1.Department of Biomedical Chemistry, Graduate School of Medicine, The University of Tokyo, 2.Department of Biochemistry, Ahmadu Bello University, 3.Department of Chemistry and Biotechnology, Graduate School of Engineering, Tottori University, 4.Department of Applied Biology, Graduate School of Science and Technology, Kyoto Institute of Technology, 5.Department of Parasitology, National Institute of Infectious Diseases)

Malaria, Drug Discovery, Mitochondria, Electron Transport Chain, Inhibitor Optimization

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