The Japanese Biochemical Society/The Molecular Biology Society of Japan

12:05 PM - 12:15 PM

[4T15L-03(3P1233)] RNA and nucleolar localization prevents toxicity and aggregation of carboxyl-terminal fragment of ALS-linked TDP43 via inhibition of the structural transition in Prion-like domain.

〇Akira Kitamura1,2, Yusaku Nakayama2, Ai Shibasaki2, Ayami Taki2, Sachiko Yuno2, Masataka Kinjo1,2 (1.Lab. of Mol. Cell Dyn., Fac. Adv. Life Sci., Hokkaido Univ., 2.Grad. Sch. of Life Sci., Hokkaido Univ.)

TDP43, RNA-binding protein, Prion, protein aggregation, Spectroscopic live-cell imaging

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