A heterozygous mutation of Polg gene causes behavioral abnormalities due to the tissue-specific accumulation of multiple mtDNA deletions in mice

Satoshi Fuke; Mizue Kametani; Yasufumi Shigeyoshi; Mie Sakashita-Kubota; Kazuyuki Yamada; Seiji Hitoshi; Tadafumi Kato

3:30 PM - 3:40 PM

[4T特p-10(3P1243)] A heterozygous mutation of Polg gene causes behavioral abnormalities due to the tissue-specific accumulation of multiple mtDNA deletions in mice

〇Satoshi Fuke^1,2, Mizue Kametani², Yasufumi Shigeyoshi³, Mie Sakashita-Kubota², Kazuyuki Yamada⁴, Seiji Hitoshi¹, Tadafumi Kato² (1.Dept. of Integrative Physiol., Shiga Univ. of Med. Sci., 2.Lab. for Mol. Dyn. of Mental Dis., RIKEN BSI, 3.Dept. Anato. Neurobiol., Kinki Univ. Facul. Med., 4.RRC, RIKEN BSI)

mitochondria, mitochondrial DNA, CPEO

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BMB2015 Biochemistry and Molecular Biology

[4T特p-10(3P1243)] A heterozygous mutation of Polg gene causes behavioral abnormalities due to the tissue-specific accumulation of multiple mtDNA deletions in mice

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