The Japanese Biochemical Society/The Molecular Biology Society of Japan

3:51 PM - 4:09 PM

[4W27-p-7] FUS regulates AMPA receptor function and FTLD/ALS-associated behavior via GluA1 mRNA stabilization

〇Tsuyoshi Udagawa1,5, Yusuke Fujioka1, Motoki Tanaka2, Daiyu Honda1, Satoshi Yokoi1, Daisuke Ibi3, Taku Nagai3, Kiyofumi Yamada3, Hirohisa Watanabe1, Masahisa Katsuno1, Kinji Ohno4, Toshifumi Inada5, Masahiro Sokabe2, Haruo Okado6, Shinsuke Ishigaki1, Gen Sobue1 (1.Dept., of Neurol., Grad. Sch. of Med., Nagoya Univ., 2.Mechanobiology Lab., Grad. Sch. of Med., Nagoya Univ., 3.Dept. of Neuropsychopharmacology and Hospital Pharmacy, Grad. Sch. of Med., Nagoya Univ., 4.Division of Neurogenetics, Grad. Sch. of Med., Nagoya Univ., 5.Grad. Sch. of Pharm. Sci., Tohoku Univ., 6.Dpt. of Brain Development and Neural Regeneration, Tokyo Metropolitan Institute of Med. Sci.)

FTLD/ALS, synapse, mRNA stability, polyadenylation

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