3:51 PM - 4:09 PM

[4W27-p-7] FUS regulates AMPA receptor function and FTLD/ALS-associated behavior via GluA1 mRNA stabilization

〇Tsuyoshi Udagawa^1,5, Yusuke Fujioka¹, Motoki Tanaka², Daiyu Honda¹, Satoshi Yokoi¹, Daisuke Ibi³, Taku Nagai³, Kiyofumi Yamada³, Hirohisa Watanabe¹, Masahisa Katsuno¹, Kinji Ohno⁴, Toshifumi Inada⁵, Masahiro Sokabe², Haruo Okado⁶, Shinsuke Ishigaki¹, Gen Sobue¹ (1.Dept., of Neurol., Grad. Sch. of Med., Nagoya Univ., 2.Mechanobiology Lab., Grad. Sch. of Med., Nagoya Univ., 3.Dept. of Neuropsychopharmacology and Hospital Pharmacy, Grad. Sch. of Med., Nagoya Univ., 4.Division of Neurogenetics, Grad. Sch. of Med., Nagoya Univ., 5.Grad. Sch. of Pharm. Sci., Tohoku Univ., 6.Dpt. of Brain Development and Neural Regeneration, Tokyo Metropolitan Institute of Med. Sci.)

FTLD/ALS, synapse, mRNA stability, polyadenylation