[4T18-03(3P1065)] A novel p53 target gene, LIMA1 is required for the suppression of cancer cell invasion

〇Tomoko Ohashi¹, Masashi Idogawa¹, Riko Umeta¹, Yasushi Sasaki¹, Takashi Tokino¹ (1.Med. Genome Sci., Res. Inst. Frontier Med., Sapporo Med. Univ.)

BMB2015 Biochemistry and Molecular Biology |Fri. Dec 4, 2015 9:20 AM - 9:30 AM

[4T18-04(3P1066)] TSPAN2-CD44 interaction is the novel therapeutic target for lung ADCs

〇Makoto Miyazaki^1,2, Ryo Otomo¹, Yuko Hibiya¹, Chihiro Otsubo¹, Naoto Yanagisawa^1,3, Toshiki Watanabe², Masato Enari¹ (1.Div. Refractory & Advanced Cancer Res., Natl. Cancer Ctr. Res. Inst., 2.Grad. Sch. of Frontier Sci., Univ. of Tokyo, 3.Tokyo College of Biotechnology)

BMB2015 Biochemistry and Molecular Biology |Fri. Dec 4, 2015 9:30 AM - 9:40 AM

[4T18-05(3P1067)] Functional analysis of estrogen-mediated BRCA2 protein

〇Mariko Umegaki¹, Nobuhide Tsurumaki², Miho Takaoka¹, Akira Nakanishi¹, Yoshio Miki^1,3 (1.Dept.Mol.Genet., Tokyo Med&Dent.Univ., 2.Dept.Technical Sales, Life Science Res., 3.Dept.Mol.Diagnousis, JFCR. The Cancer Inst.)

BMB2015 Biochemistry and Molecular Biology |Fri. Dec 4, 2015 9:40 AM - 9:50 AM

[4T18-06(3P1068)] Analysis of the mechanism by which fad104 regulates STAT3 signaling in cancer cells

〇Daiki Katoh¹, Makoto Nishizuka¹, Shigehiro Osada¹, Masayoshi Imagawa¹ (1.Dept. of Mol. Biol., Grad. Sch. of Pharm. Sci., Nagoya City Univ.)

BMB2015 Biochemistry and Molecular Biology |Fri. Dec 4, 2015 9:50 AM - 10:00 AM

[4T18-07(3P1069)] Loss of FBW7 Promotes Chromosomal Instability through Cyclin E1/ CDK2-mediated CENP-A Phosphorylation

〇Mamoru Takada^1,2, Aussie Suzuki¹, Qing Zhang¹ (1.Univ. of North Carolina　at Chapel Hill, 2.Grad. Sch. of Med.,　Chiba Univ.)

BMB2015 Biochemistry and Molecular Biology |Fri. Dec 4, 2015 10:00 AM - 10:10 AM

[4T18-08(3P1070)] Proteosomal degradation of p47 by HTLV-1 Tax and p47 promoter methylation enhanced CADM1 expression in ATLL cells

Ichiro Nishikata¹, Shingo Nakahata¹, Tomonaga Ichikawa¹, Masahiro Fujii², Hidekatsu Iha³, Yuetsu Tanaka⁴, 〇Kazuhiro Morishita¹ (1.Dept. of Med. Sci., Faculty of Med., Univ. of Miyazaki, 2.Graduate School of Medical and Dental Sciences, University of Niigata,, 3.Department of Microbiology, Oita University Faculty of Medicine, Yufu, Oita, Japan, 4.Department of Immunology, Graduate School of Medicine, University of Ryukyus)

BMB2015 Biochemistry and Molecular Biology |Fri. Dec 4, 2015 10:10 AM - 10:20 AM

[4T18-09(3P1071)] CD74-NRG1, a fusion gene product, leads to ErbB-NFĸB-IGF2 autocrine/paracrine circuit and confers cancer stem cell properties

〇Takahiko Murayama^1,2,3, Takashi Nakaoku⁴, Masato Enari⁵, Tatsunori Nishimura¹, Kana Tominaga³, Asuka Nakata¹, Arinobu Tojo³, Sumio Sugano², Takashi Kohno⁴, Gotoh Noriko^1,3 (1.Div. Cancer Cell Biol., Cancer Res. Inst. Kanazawa Univ., 2.Lab. Functional Genomics, Grad. Sch. Frontier Sci., Univ. Tokyo, 3.Div. Mol. Therapy, IMS, Univ. Tokyo, 4.Div. Genome Biol., Natl. Cancer Ctr. Res. Inst., 5.Div. Refractory Cancer Res., Natl. Cancer Ctr. Res. Inst.)

BMB2015 Biochemistry and Molecular Biology |Fri. Dec 4, 2015 10:20 AM - 10:30 AM

[4T18-10(3P1072)] TGF-β2-TGFBR3 signal is a key regulator of cancer-initiating cell maintenance in clear cell renal cell carcinoma

〇Jun Nishida¹, Shogo Ehata¹, Kohei Miyazono¹ (1.Dept. of Mol. Pathol., Grad. Sch. of Med., Univ. of Tokyo)

BMB2015 Biochemistry and Molecular Biology |Fri. Dec 4, 2015 10:30 AM - 10:40 AM

[4T18-11(3P1073)] Senescence derived from glioma stem cell differentiation and its implication in the tumor progression

〇Rie Ouchi^1,2, Sachiko Okabe¹, Toshiro Migita¹, Ichiro Nakano³, Hiroyuki Seimiya^1,2 (1.Div. Mol. Biother., Cancer Chemother. Ctr., JFCR, 2.Grad. Sch. Frontier Sci., Univ. Tokyo, 3.Dept. Neurol. Surg., Ohio State Univ., USA)

BMB2015 Biochemistry and Molecular Biology |Fri. Dec 4, 2015 10:40 AM - 10:50 AM

[4T18-12(3P1074)] Glim enhance the formation and development of gliomas in mouse and human

〇Naoki Ohtsu¹, Yuka Nakatani², Daisuke Yamashita³, Takanori Ohnishi³, Toru Kondo^1,4 (1.Dept. of Stem Cell Biology、IGM Hokkaqido Univ., 2.RIKEN, CLST, 3.Dept. of Neurosurg., Med., Ehime Univ., 4.RIKEN, CDB)

BMB2015 Biochemistry and Molecular Biology |Fri. Dec 4, 2015 10:50 AM - 11:00 AM