[1LBA-064] In silico screening and synthesis of chalcones acting against the cancer target topoisomerase IIα

〇Kanyani Sangpheak¹, Monika Mueller², Chonticha Suwattanasophon², Peter Wolschann^2,3, Warinthon Chavasiri⁴, Nawee Kungwan^5,6, Chompoonut Rungnim⁷, Thanyada Rungrotmongkol^8,9 (1.Program in Biol., Faculty of Sci., Chulalongkorn Univ., Bangkok 10330, Thailand.., 2.Dept. of Pharmaceutical Technology and Biopharmaceutics., Univ. of Vienna., Vienna 1090, Austria, 3.Institute of Theoretical Chemistry., Univ. of Vienna, Vienna 1090, Austria, 4.Natural Products Research Unit., Dept. of Chemistry., Fac. of Sci., Chulalongkorn Univ., Bangkok 10330, Thailand., 5.Dept. of Chemistry, Fac. of Sci., Chiang Mai, Univ., Chiang Mai, 50200, Thailand., 6.Research Center on Chemistry for Development of Health Promoting Products from Northern Resources, Chiang Mai University, Chiang Mai, 50200, Thailand., 7.Nanoscale Simulation Laboratory, National Nanotechnology Center, National Science and Technology Development Agency, Pathum Thani, 12120, Thailand, 8.Structural and Computational Biology Research Group, Dept. of Biochemistry, Fac. of Sci., Chulalongkorn Univ., Bangkok 10330, Thailand, 9.Ph.D. Program in Bioinformatics and Computational Biology, Grad. Sch., Chulalongkorn Univ., Bangkok 10330, Thailand)

Chalcone、Human topoisomerase II、Synthesis、Molecular docking、Molecular dynamics simulation