[1LBA-079] Effect of sodium-glucose cotransporter 2 (SGLT2) inhibition on weight loss is partly mediated by liver-brain-adipose neurocircuitry

〇Yoshikazu Sawada^1,2, Yoshihiko Izumida^1,3, Yoshinori Takeuchi^1,2, Yuichi Aita^1,2, Nobuhiro Wada^1,3, EnXu Li^1,3, Yuki Murayama^1,2, Xianying Piao^1,2, Akito Shikama^1,2, Yukari Masuda^1,3, Makiko Nishi^1,2, Midori Kubota^1,3, Motohiro Sekiya², Takashi Matsuzaka², Yoshimi Nakagawa², Yasushi Kawakami², Takashi Kadowaki³, Hitoshi Shimano², Naoya Yahagi^1,2,3 (1.Nutrigenomics Research Group, Sch. of Med., Univ. of Tsukuba, 2.Dept. of Internal Medicine, Sch. of Med., Univ. of Tsukuba, 3.Dept. of Internal Medicine, hospital, Univ. of Tokyo)