[1P-0127] Ternary complex of human ROR gamma ligand binding domain, inverse agonist and SMRT peptide reveals a unique mechanism of co-repressor recruitment

Masato Noguchi¹, 〇Akihiro Nomura¹, Ken Murase¹, Satoki Doi¹, Keishi Yamaguchi¹, Kazuyuki Hirata², Makoto Shiozaki², Shintaro Hirashima², Masayuki Kotoku², Takayuki Yamaguchi³, Yoshiaki Katsuda³, Steensma Ruo⁴, Li Xioalin⁴, Tao Haiyan⁴, Tse Bruno⁴, Fenn Morgan⁴, Babine Robert ⁴, Bradley Erin⁴, Crowe Paul⁴, Thacher Scott⁴, Tsuyoshi Adachi¹, Masafumi Kamada¹ (1.Pharmaceutical Frontier Research Laboratories, Central Pharmaceutical Research Institute, Japan Tobacco Inc., 2.Chemical Research Laboratories, Central Pharmaceutical Research Institute, Japan Tobacco Inc., 3.Biological Pharmacological Research Laboratories, Central Pharmaceutical Research Institute, Japan Tobacco Inc., 4.Orphagen Pharmaceuticals)

Autoimmune disease、Th17cells、Nuclear receptor、Inverse agonist、Co-repressor